Low-frequency ultrasound (US) applied to skin (sonophoresis) has been investigated to enhance the percutaneous exaltation of respective drugs. Histamine is usually used in allergy investigations. We aimed to investigate, in a irregular study, the percutaneous ingress of histamine with sonophoresis. Their correct forearm was divided into cardinal zones, which were randomly allotted a treatment: no US, US).
Skin penetration-enhancing effect of drugs by phonophoresis - ScienceDirect
The skin entry enhancement of 9 drugs by phonophoresis was analyzed using ultrasonic condition at 150 k Hz in in vitro skin interpenetration experiments conducted to shed light on the field and permeability constant of drugs, and hydrodynamic parameters of skin. The state of lipotropic drugs after sonication was similar to that before sonication, whereas that for deliquescent drugs after sonication was accumulated 6.88-7.43-fold. permeableness coefficients of deliquescent drugs through and through full thickness aliveness with ultrasound were individual to that through minimal skin without ultrasound, while that of lipophilic drugs was alone slimly changed.
Combined Use of Ultrasoundand Other Physical Methods of SkinPenetration Enhancement | SpringerLink
In this chapter, the alinement of ultrasound and else physiological enhancers, specified as injections, electroporation, microneedles, and microdermabrasion, as asymptomatic as the simultaneous use of low-frequency and high-frequency ultrasound, for enhanced transdermal delivery applications, is discussed. tho' the field of battle of sonophoresis is playing period 70 years old, there are amazingly few reported studies aimed at combining ultrasonography with other material enhancers, omit for iontophoresis. Further, many of the studies individual been conducted in a proof-of-concept manner, with prosody on the practicability of the underlying idea, but with pocket-sized mechanical discussion.